Mixed-Mode Columns

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Mixed- mode chromatography is a sophisticated separation technique that harnesses the synergistic effects of at least two distinct interactions to achieve the simultaneous retention and separation of both organic and inorganic compounds in a single chromatographic run. The design of the stationary phase determines various controllable mechanisms of interactions crucial for effective separation, including:

  • 1. Reversed-phase, anion-exclusion and cation-exclusion
  • 2. Reversed-phase and pi-pi
  • 3. Reversed phase, pi-pi and cation-exchange
  • 4. HILIC cation and anion exchange

The application of mixed-mode chromatography offers several distinct benefits, emphasizing its unique properties, unprecedented selectivity, and additional advantages.

Unique properties:

  • 1. Explore alternative selectivity beyond RP, Normal phase, HILIC and ion-exchange methodologies for a refined chromatographic experience.
  • 2. Experience a notable augmentation in the retention time of ionizable analytes, ensuring heightened precision in your analytical endeavors.
  • 3. Achieve the retention of polar and ionizable compounds sans the need for an ion-pairing reagent, exemplifying the inherent efficiency of our chromatographic approach.
  • 4. Unlock the capability to comprehensively analyze both organic and inorganic molecules within a single run, streamlining your analytical processes.
  • 5. Attain impeccably shaped peaks for charged analytes, courtesy of ionizable groups strategically positioned on the chromatographic surface.
  • 6. Ensure complete compatibility with a diverse array of detection techniques, including the advanced capabilities of mass spectrometry, empowering your analytical methodologies.
  • 7. Increased flexibility with the freedom to choose from a variety of diluents for your analytes, tailoring your chromatographic protocols to meet your specific needs.
  • 8. Robust stationary phases and methodologies, underscoring the resilience and reliability of our chromatographic applications. Embark on a comprehensive journey with our mixed-mode chromatography approach, offering not only unparalleled versatility in separation but also paving the way for heightened selectivity. It stands as a potent tool in both analytical and preparative chromatography applications, ensuring a powerful and refined chromatographic experience.